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KMID : 0880220220600030300
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Journal of Microbiology
2022 Volume.60 No. 3 p.300 ~ p.307
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Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
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Kim Na-Eun
Song Yoon-Jae
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Abstract
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Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for limiting SARS-CoV-2 infection, aberrant activation of these innate immune responses is associated with COVID-19 pathogenesis. In this review, we focus our discussion on recent findings on SARS-CoV-2-induced type I and III IFNs and NLRP3 inflammasome responses and the viral proteins regulating these mechanisms.
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KEYWORD
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inflammasome, interferon, severe acute respiratory syndrome corona virus 2
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